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H H S Department of Health and Human Services
U.S. Department of Health and Human Services
Health Resources and Services Administration

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Review of Adverse Effects of Vaccines

In 2008 HRSA contracted with the Institute of Medicine (IOM) to review the epidemiological, clinical, and biological evidence regarding adverse health events associated with specific vaccines covered by the Vaccine Injury Compensation Program.

The vaccines to be reviewed were

  • varicella vaccines,
  • influenza vaccines,
  • hepatitis B vaccine,
  • human papillomavirus virus vaccines,
  • hepatitis A vaccines,
  • meningococcal vaccines,
  • measles-mumps rubella vaccines, and
  • diphtheria, tetanus, pertussis vaccines

The committee authored a consensus report in 2011 with conclusions on the evidence bearing on causality and the evidence regarding the biological mechanisms that underlie specific theories for how a specific vaccine is related to a specific adverse event.

This information reflects the current thinking of the United States Department of Health and Human Services on the topics addressed. This information is not legal advice and does not create or confer any rights for or on any person and does not operate to bind the Department or the public. The ultimate decision about the scope of the statutes authorizing the VICP is within the authority of the United States Court of Federal Claims, which is responsible for resolving claims for compensation under the VICP.
Measles Vaccine Safety

The measles vaccine (MMR) has a long record of safety. Serious adverse reactions from MMR are rare.

The vaccine protects children against dangerous, even deadly diseases and should be given as recommended, when a child is between 12 through 15 months of age. If you wait to give it later, your child could get measles, mumps, and/or rubella, all of which remain a threat in the U.S. Learn more: Understanding MMR Vaccine Safety (PDF - 494 KB)

Protect Your Child from Measles