340B Office of Pharmacy Affairs Information System

HRSA places a high priority on the integrity of the 340B Program and uses existing authorities to provide oversight to both covered entities and manufacturers. In accordance with the statute, HRSA is launching a new, integrated information system that focuses on three key priorities: security; user accessibility; and accuracy.  The 340B Office of Pharmacy Affairs Information System (340B OPAIS) will increase the integrity and effectiveness of 340B covered entity and manufacturer information. It will also ensure every authorized user of the system will now have his or her own user account and will be granted appropriate roles by HRSA. 

340B Office of Pharmacy Affairs Information System (OPAIS)
Access 340B OPAIS to find:

  • covered entity and manufacturer records,
  • user accounts,
  • change requests,
  • re-certification, and
  • registrations

340B OPAIS System Highlights

Educational Resources

340B OPAIS FAQs

Date Last Reviewed:  February 2018


340B OPAIS News

Welcome to the new 340B Office of Pharmacy Affairs Information System (340B OPAIS), a system with upgraded security and user functionality features. Information related to the 340B OPAIS will be submitted via electronic communication and featured on this page.