HIV/AIDS Pandemic

Sub-Saharan Africa is the most affected region in the global AIDS epidemic. It accounts for about two-thirds (66%) of all people infected with HIV globally. In 2014, an estimated 25.8 million people in that region were living with HIV. Of those, 1.4 million adults and children were newly infected. In addition, 790,000 people died from the disease that year. Worldwide, an estimated 2 million people were newly infected, and 1.2 million people died of AIDS. In 2015, the Joint United Nations Programme on HIV/AIDS (UNAIDS) estimated that 36.9 million people were living with HIV worldwide.

President’s Emergency Plan for AIDS Relief (PEPFAR)

Map identifying the following countries with PEPFAR funding: Angola Asia Regional (China, Laos, and Thailand) Botswana Burundi Burma Cambodia  Cameroon Caribbean Regional (Antigua and Barbuda, Bahamas, Barbados, Dominica, Grenada, Jamaica, St. Kitts and Nevis, St. Lucia, St. Vincent, Suriname, and Trinidad and Tobago) Central America Regional (Belize, Costa Rica, El Salvador, Guatemala, Honduras, Nicaragua, and Panama) Central Asia Regional (Kazakhstan, Kyrgyz Republic, Tajikistan, Turkmenistan, and Uzbekistan) Côte d'Ivoire Democratic Republic of the Congo Dominican Republic Ethiopia Ghana Guyana Haiti India Indonesia Kenya Lesotho Malawi Mozambique Namibia Nigeria Papua New Guinea Rwanda South Africa South Sudan Swaziland Tanzania Uganda Ukraine Vietnam Zambia Zimbabwe

History of PEPFAR 

On May 27, 2003, the United States Leadership Against Global HIV/AIDS, Tuberculosis, and Malaria Act of 2003 (Public Law 108–25) was signed into law creating the President’s Emergency Plan for AIDS Relief (PEPFAR). PEPFAR is the largest commitment ever made by any nation for an international health initiative dedicated to a single disease. The plan emphasizes a “whole government” response. It draws from each agency’s core competencies to provide the most comprehensive, coordinated, and targeted interventions. Many federal departments and agencies are involved in PEPFAR’s implementation, including the U.S. Department of Health and Human Services (HHS), U.S. Department of State, U.S. Agency for International Development (USAID), U.S. Department of Defense, and the Peace Corps.


  • Impact: efficient and effective control of the HIV epidemic
  • Efficiency: increased transparency, oversight, and accountability across PEPFAR
  • Sustainability: sustainable governance models and increased country fiscal contributions and local partner implementation
  • Partnership: renewed national and global commitments to an AIDS-free generation
  • Human Rights: promotion and protection of human rights for all, including LGBT people, women and girls, and other vulnerable populations
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