Adding HLA DQA1 Unacceptable Antigen Equivalences Table

Proposal overview

Status: Implemented

Sponsoring Committee: Histocompatibility

Strategic Goal: Promote living donor and transplant recipient safety

Effective date: 9/12/2017

Policy notice (PDF - 146 KB) (7/2016)

Policy notice-executive committee action (PDF - 195 KB) (6/2017)

System updates for this project include changes outlined in the Update HLA equivalency tables proposal, approved by the board in December 2015.

Problem statement

This proposal intends to bridge a gap between the science and practice of human leukocyte antigen (HLA) compatibility assessments and the realities of computer programming. Policy approved by the OPTN/UNOS Board of Directors in November 2014 requires HLA typing for HLA-DQA1 for deceased donors to be reported to the OPTN, and requires UNOS to change UNet^SM programming to allow transplant programs to report DQA1 as an unacceptable antigen. This proposal adds an HLA DQA1 equivalency table to policy that identifies the relationship between parent antigens and corresponding allelic subtypes. The addition of the table allows UNOS staff to program data entry for DQA1 unacceptable antigens/alleles, removing concerns about patient safety due to human error and incorrect data entry.

Background

Board briefing paper (PDF - 394 KB) (6/2016)

Public comment proposal (PDF - 372 KB) (1/2016)

Comments

The comment period for this proposal is now closed.