340B Drug Pricing Program

Guidance to 340B providers in Puerto Rico and the Virgin Islands — Public Health Emergency Declaration by the Secretary

HRSA recognizes that circumstances surrounding disaster relief efforts warrant flexibility for entities eligible for participation in the 340B Program.

Therefore, HRSA is allowing eligible entities in Puerto Rico and the Virgin Islands to immediately enroll for the 340B Program during the Public Health Emergency Declaration by the Secretary, rather than having to wait for the normal quarterly registration period. HRSA believes this will enable these entities to meet the needs of the residents affected by this disaster. If you are in any of these states and would like to enroll, please contact the 340B Prime Vendor Program at apexusanswers@340bpvp.com or 1-888-340-2787.

In addition, please view the following information for flexibilities allowed during a Public Health Emergency Declaration by the Secretary.  

New registrations are accepted October 1-15, January 1-15, April 1-15 and July 1-15.


pictures of prescription drugsThe 340B Program enables covered entities to stretch scarce Federal resources as far as possible, reaching more eligible patients and providing more comprehensive services.

Manufacturers participating in Medicaid, agree to provide outpatient drugs to covered entities at significantly reduced prices.

Eligible health care organizations/covered entities are defined in statute and include HRSA-supported health centers and look-alikes, Ryan White clinics and State AIDS Drug Assistance programs, Medicare/Medicaid Disproportionate Share Hospitals, children’s hospitals, and other safety net providers. See the full list of eligible organizations/covered entities.

To participate in the 340B Program, eligible organizations/covered entities must register and be enrolled with the 340B program and comply with all 340B Program requirements. Once enrolled, covered entities are assigned a 340B identification number that vendors verify before allowing an organization to purchase 340B discounted drugs.

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Date Last Reviewed:  May 2018


OPA Program Update – July 2018

OPA Program Update – June 2018

OPA Program Update – May 2018

The new 340B Office of Pharmacy Affairs information System (340B OPAIS) is now live and ready for participating Covered Entities and Manufacturers to create User Accounts and access the system.  Additional educational resources can be found on the 340B OPAIS web link.

Contact OPA

Office of Pharmacy Affairs
Health Resources and Services Administration
5600 Fishers Lane, 08W05A
Rockville, MD 20857

Recertify your 340B registration every year

Contact the 340B Prime Vendor Program

340B Prime Vendor Program website
1-888-340-2787 (Monday – Friday, 9 a.m. – 6 p.m. ET)