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U.S. Department of Health and Human Services
Health Resources and Services Administration
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Application Guides: SF-424 and SF-424 R&R

SF-424 Application Guide (PDF - 847 KB)

SF-424 R&R Application Guide (PDF - 932) This "version 2" R&R guide applies to HRSA's FY17 R&R FOAs posted after June 1, 2016


The Application Guides and video provide detailed instructions to help you prepare and submit the following through using the Workspace process: new, competing continuation, and competing supplement applications that require the Application for Federal Assistance SF-424 Non-Construction and SF-424 R&R (Research & Related) application packages.

The Guides, companion documents to the notices of funding opportunities (NOFOs), present general information related to the application preparation and submission process. HRSA's Division of Grants Policy in the Office of Federal Assistance Management periodically updates and maintains this document.

The video and documents do not replace program-specific guidance provided in NOFOs.

Application Basics

Organizations, not individuals, are eligible to apply. Completing a grant application can take 40 hours or more. Be sure to avoid common mistakes that stop an application before it is even reviewed. 

First step: Register

Are You an Eligible Organization?

Submit Your Application Before the Deadline

Understand the Grant Process: Pre-Award, Post-Award and Closeout (PDF - 296 KB) | recorded webcast

How to Apply - Top 10 Tips for Applicants

"Debunk the Myths" about grant application -- animated video series

Dictionary of Grant Terms Application Help (FAQs & troubleshooting tips)

Writing a Responsive Application (PDF - 2 MB)